Translocation (14;15) (q32;q13) in B cell chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
B-cell Chronic Lymphocytic Leukemia
Purpose: To review the recent major advances in the molecular and cell biology of B-cell chronic lymphocytic leukemia (B-CLL). Methods: Weanalyzed thenatureofmalignantB-CLLB cells and their interactions with the microenvironment. Results: B-CLL is a malignancy of a mantle zonebased subpopulation of anergic, self-reactive, activated CD51 B cells devoted to the production of polyreactive natural ...
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Alemtuzumab, a humanized monoclonal antibody, is thought to destroy cancer cells through immune system stimulation or apoptosis induction (programmed cell death). In case series studies using alemtuzumab as salvage therapy, about a third of patients with B-cell chronic lymphocytic leukemia (B-CLL), who were otherwise refractory to chemotherapy, improved. Anti-tumour activity was also observed w...
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BACKGROUND B cell chronic lymphocytic leukemia (B-CLL) is the most common adult leukemia in the Western world. Although therapeutic advances have notably improved the outcome for many patients, B-CLL remains an incurable disease. The purpose of this study was to search for therapeutic drugs based on altered pathways in individual patients. MATERIAL AND METHODS Genes from microarray data were ma...
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Mutations in the ATM gene located on the long arm of chromosome 11 at 11q22–23 cause ataxia-telangiectasia, an autosomal recessive disorder that is associated with increased incidence of malignancy and, particularly, lymphoid tumors. A role for ATM in the development of sporadic T-cell chronic leukemias is supported by the finding of loss of heterozygosity at 11q22–23 and ATM mutations in leuke...
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Sir, CD79b monoclonal antibody (B29) identifies a Bcell restricted molecule that is part of the mb1/B29 disulphide-linked heterodimer which is non-covalently associated with membrane IgM and IgG to constitute the B-cell antigen receptor complex.1 Both B29 and mb1 are restricted to B-lymphocytes, first appearing on the surface at the pre-B-cell stage and remaining through all stages of B-cell di...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1993
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.2830440118